Īlthough governments and organizations all over the globe have taken many precautions to prevent the pandemic's spread, the only way to stop the threat is to find a vaccine. In addition, new SARS-CoV-2 variations have evolved due to the high transmission rates, posing a new challenge in managing the current epidemic. SARS-CoV-2 infections can result in many clinical symptoms, ranging from asymptomatic or mild infections to severe lung and multi-organ infections resulting in death. As a result, SARS-CoV-2 was labeled a global pandemic by the World Health Organization in March 2020. Also, help reduce vaccine hesitancy among individuals worried about vaccine safety and possible adverse effects.Ĭoronavirus 2 (SARS-CoV-2) emerged at the end of 2019 and quickly spread worldwide, causing a significant mortality and morbidity rate. We hope that our results will reassure the public that the benefits of vaccination far exceed the dangers. Anaphylactic shock or severe reactions are rare. Local reactions like pain at the injection site are the most common.
Our study reveals that side effects after the Pfizer-BioNTech vaccine are common, but they are usually mild and self-limited.
The average occurs side effects in females at 69.8% compared with males 30.2%. The average side effects after the first dose were 79% compared with 84% after the second dose. Average of the most frequent side effects of 14 studies were injection site pain 77.34%, fatigue 43%, muscle pain 39.67%, local swelling 33.57%, headache 33.27%, joint pain 25.75%, chills 18.34%, fever 18%, itching 9.38%, lymph nodes swelling 7.86%, nausea 7.58%, dyspnea 7.86%,and diarrhea 6.36%. The total number of participants in the 14 studies was 10,632 participants. The included searching terms were a combination of “Pfizer vaccine and Side effects,” “BioNTech vaccine and side effects,” and “BNT162b2 vaccine and side effects,” as well as all synonyms. Fourteen articles met the study inclusion criteria. A total of 107 PubMed and Google Scholar publications were screened for Pfizer-BioNTech COVID-19 vaccine side effects. This systematic review was undertaken to assess the Pfizer-BioNTech vaccine side effects by reviewing the previous studies. Resulting in various adverse effects that may emerge after vaccination. The Pfizer-BioNTech vaccine is the first mRNA-based vaccination that enhances immunity. It was considered a vital component of living endemically with COVID-19. Vaccinations prevented severe clinical complications of COVID-19.
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